I'll give it a go, just for kicks and giggles:
South Region preditions, Round one, winners paired for next round:
Christopher Newport (USAC Champ) at Hardin-Simmons
Mary Hardin-Baylor/East Texas Baptist at Trinity
Rationale: ACFC will come down to last week of season. If Salisbury wins, the committee will likely shy away from a Salisbury/CNU rematch in the first round. Texas sub-bracket in-tact w/ likely a one-time-only flight. CNU gets the long road game because of two-loss record (albeit to two potential playoff teams).
Thomas More (PAC Champ) at Bridgewater
Salisbury (ACFC Champ) at John's Hopkins (CC Champ)
Rationale: As above w/ regard to Salisbury. Really, IMO, these four teams are interchangeable as far as who hosts whom, due to relatively close geographic proximity.
If DePauw, Thiel or W&J get a bid, then I think they get shipped to another region.
Predicted Pool A's from South Region: HSU, Trinity, Bridgewater, Christopher Newport, John's Hopkins
Predicted Pool B's from South Region: Salisbury, Thomas More
Predicted Pool C's from South Region: Mary Hardin-Baylor or East Texas Baptist